
Ingredients Optimised
The effectiveness of any supplement depends fundamentally on its ingredients. Selecting the right nutrients in their optimal forms and dosages requires a delicate balance of scientific understanding, quality sourcing, and evidence-based formulation.
From choosing superior forms of vitamins to determining therapeutic dosages, every ingredient decision we make is guided by clinical research rather than cost considerations. We validate each formulation through rigorous testing, ensuring that our carefully selected ingredients deliver meaningful benefits while maintaining the highest standards of purity.
This approach represents more than just ingredient selection - it's a comprehensive commitment to creating supplements that genuinely support your health. Because when it comes to supplementation, what you put into your body matters.
Evidence-Based Formulation
Selecting ingredients for our Puramins supplements isn't about following trends or making decisions based on marketing appeal. Every formula begins with extensive research through:
- Peer-reviewed scientific journals
- Clinical studies and trials
- Authoritative medical textbooks
- Respected publications
- Evidence-based medical databases
- Established healthcare reference works
This comprehensive approach means we select only nutrients that have proven absorption and effectiveness, with dosages determined by clinical research rather than marketing considerations. Every decision in our formulation process is guided by current scientific understanding.
When you choose a Puramins supplement, you're getting a product whose effectiveness is supported by robust research, not marketing claims or popular trends.
Third-Party Testing
Scientific validation doesn't stop at ingredient selection. We verify the effectiveness of our formulations through multiple stages of testing and quality control. This begins with careful analysis of each raw ingredient and continues through to finished product testing.
Working with leading UK laboratories, we conduct comprehensive assessments of our supplements. These third-party tests verify potency by confirming that ingredient levels match our label claims exactly. Additionally, each batch undergoes thorough safety screening, including tests for heavy metals and extensive microbiological analysis. This includes testing for harmful organisms such as yeasts and moulds, Escherichia coli, Coagulase positive staphylococci, Enterobacteriaceae and Salmonella, ensuring the highest standards of product safety and quality.
This rigorous testing programme provides independent verification that our supplements not only contain exactly what we claim, but also meet the strictest standards for purity and safety. When you choose Puramins, you can be confident that what's stated on the label matches what's in the bottle.
The Importance of Bioavailability
The bioavailability of a nutrient—how well your body can absorb and utilise it—is crucial for supplement effectiveness (1,2,3,4,5). Even the highest-quality ingredient won't benefit your health if your body cannot properly absorb it.
At Puramins, we carefully select highly bioavailable forms of nutrients, ensuring that your body can effectively utilise what you're taking. This means you get better value for money and, more importantly, better results for your health.
Several factors influence how well supplements are absorbed:
Form
The chemical form of a nutrient significantly affects its absorption. For example, in a magnesium supplement, ideal forms include citrate, malate, taurate or glycinate (amongst others), whilst poor choices would be magnesium oxide or aspartate (6).
Delivery
The delivery system—whether capsules, tablets, gummies, liquids or other forms—plays an important role in absorption. Tablets and gummies need to break down completely before their nutrients can be absorbed, which can be challenging for many people.
Purity
Many supplements contain one or more additives that can delay, interfere with or reduce the level of absorption in the body.
Learn MoreSynergistic Relationships
Some nutrients work together to enhance absorption. Vitamin D aids calcium absorption, whilst Vitamin C can improve iron uptake. Conversely, some nutrients can compete for absorption, such as zinc and iron, which is why timing and formulation matter (7,8).
Timing
When and how you take supplements, with or without food, time of day, and combining with other supplements, can significantly affect bioavailability (9).
Individual Factors
Your age, gut health, medical conditions and even the medications you take can impact nutrient absorption (10,11,12,13).
The Cost of Quality
If you look around, you'll no doubt see supplements available at much lower prices compared to Puramins products. Price is naturally a significant factor for many people, especially when living costs are high.
However, examine these cheaper products closely and you'll typically find low dosages, ineffective forms of nutrients, poor delivery systems and, almost invariably, one or more unnecessary additives. Important questions often go unanswered: Has the supplement been ethically produced? Is the packaging recyclable? Are third-party test results available?
We always aim to offer fair pricing that reflects our quality and commitment. Whilst this means our supplements may cost more than average, we believe in never compromising on quality, sustainability or transparency. We trust you'll find our products worth the investment in your health.
Ingredients chosen with purpose, formulated for impact.
1) Bayes J, Agrawal N, Schloss J. The Bioavailability of Various Oral Forms of Folate Supplementation in Healthy Populations and Animal Models: A Systematic Review. 2019. J Altern Complement Med Feb;25(2):169-180. (https://pubmed.ncbi.nlm.nih.gov/30010385/)
2) Šimoliūnas E, Rinkūnaitė I, Bukelskienė Ž, Bukelskienė V. Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model. 2019. Medicina (Kaunas, Lithuania), 55(6), 265. (https://pmc.ncbi.nlm.nih.gov/articles/PMC6631968/)
3) Le J. Drug Bioavailability. MSD Manual. (https://www.msdmanuals.com/professional/clinical-pharmacology/pharmacokinetics/drug-bioavailability?ruleredirectid=742)
4) Price G, Patel D. Drug Bioavailability. National Library of Medicine. 2023. (https://www.ncbi.nlm.nih.gov/books/NBK557852/)
5) Chiou W. The rate and extent of oral bioavailability versus the rate and extent of oral absorption: clarification and recommendation of terminology. 2001. J Pharmacokinet Pharmacodyn Feb;28(1):3-6. (https://pubmed.ncbi.nlm.nih.gov/11253613/)
6) Lindberg J, Zobitz M, Poindexter J, Pak C. Magnesium bioavailability from magnesium citrate and magnesium oxide. 1990. J Am Coll Nutr 1990 Feb;9(1):48-55. (https://pubmed.ncbi.nlm.nih.gov/2407766/)
7) Heaney RP. Vitamin D and calcium interactions: functional outcomes. Am J Clin Nutr. 2008 Aug;88(2):541S-544S. (https://pubmed.ncbi.nlm.nih.gov/18689398/)
8) Solomons NW. Competitive interaction of iron and zinc in the diet: consequences for human nutrition. J Nutr. 1986 Jun;116(6):927-35. (https://pubmed.ncbi.nlm.nih.gov/3522825/)
9) Dawson-Hughes B, Harris SS, Palermo NJ, Ceglia L, Rasmussen H. Meal conditions affect the absorption of supplemental vitamin D3 but not the plasma 25-hydroxyvitamin D response to supplementation. J Bone Miner
Res. 2013 Aug;28(8):1778-83. (https://pubmed.ncbi.nlm.nih.gov/23427007/)
10) Kassis A, Fichot M, Horcajada M, Horstman A, Duncan P, Bergonzelli G, Preitner N, Zimmermann D, Bosco N, Vidal K, Donato-Capel L. Nutritional and lifestyle management of the aging journey: A narrative review. 2013. Frontiers in nutrition, 9, 1087505. (https://pmc.ncbi.nlm.nih.gov/articles/PMC9903079/)
11) Saltzman JR, Russell RM. The aging gut. Nutritional issues. Gastroenterol Clin North Am. 1998 Jun;27(2):309-24. (https://pubmed.ncbi.nlm.nih.gov/9650019/)
12) Woudstra T, Thomson AB. Nutrient absorption and intestinal adaptation with ageing. Best Pract Res Clin Gastroenterol. 2002 Feb;16(1):1-15. (https://pubmed.ncbi.nlm.nih.gov/11977925/)
13) Zuvarox T, Belletieri C. Malabsorption Syndromes. 2023. StatPearls. (https://www.ncbi.nlm.nih.gov/books/NBK553106/)